Multipotent

Multipotent

Multipotency describes progenitor cells which have the gene activation potential to differentiate into multiple, but limited cell types. For example, a multipotent blood stem cell is a hematopoietic cell — and this cell type can itself differentiate into several types of blood cell types like lymphocytes, monocytes, neutrophils, etc., but cannot differentiate into brain cells, bone cells or other non-blood cell types.

New research related to multipotent cells suggests that multipotent cells may be capable of conversion into unrelated cell types. In one case, fibroblasts were converted into functional neurons. In another case, human umbilical cord blood stem cells were converted into human neurons. Research is also focusing on converting multipotent cells into pluripotent cells 

Multipotent cells are found in many, but not all human cell types. Multipotent cells have been found in adipose tissue, cardiac cells, bone marrow, and mesenchymal stromal cells (MSCs) which are found in the third molar.

MSCs may prove to be a good, reliable source for stem cells because of the ease in collection of molars at 8–10 years of age and before adult dental calcification. MSCs can differentiate into osteoblasts, chondrocytes, and adipocytes.