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myasthenia gravis: ice test

Applying ice to weak muscle groups characteristically leads to improvement in strength of those muscles. Applying ice for 5 minutes to the muscles reportedly has a sensitivity and specificity of 76.9% and 98.3%, respectively, for the identification of MG. It is thought that acetylcholinesterase is inhibited at the lower temperature and that this is the basis for this diagnostic test.

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