The
ensuing S phase starts when DNA replication commences; when it is
complete, all of the chromosomes have been replicated, i.e., each
chromosome has two (sister) chromatids. Thus, during this phase, the
amount of DNA in the cell has effectively doubled, though the ploidy of
the cell remains the same. During this phase, synthesis is completed as
quickly as possible due to the exposed base pairs being sensitive to
external factors such as any drugs taken or any mutagens (such as
nicotine)
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