Bone marrow transplantation usually requires that the recipient's own bone marrow be destroyed ("myeloablation"). Prior to "engraftment"
patients may go for several weeks without appreciable numbers of white
blood cells to help fight infection. This puts a patient at high risk of
infections, sepsis and septic shock, despite prophylactic antibiotics.
However, antiviral medications, such as acyclovir and valacyclovir, are
quite effective in prevention of HSCT-related outbreak of herpetic
infection in seropositive patients. The immunosuppressive agents
employed in allogeneic transplants for the prevention or treatment of
graft-versus-host disease further increase the risk of opportunistic
infection. Immunosuppressive drugs are given for a minimum of 6-months
after a transplantation, or much longer if required for the treatment of
graft-versus-host disease. Transplant
patients lose their acquired immunity, for example immunity to childhood
diseases such as measles or polio. For this reason transplant patients
must be re-vaccinated with childhood vaccines once they are off
immunosuppressive medications.myeloablation : Bone marrow transplantation
Bone marrow transplantation usually requires that the recipient's own bone marrow be destroyed ("myeloablation"). Prior to "engraftment"
patients may go for several weeks without appreciable numbers of white
blood cells to help fight infection. This puts a patient at high risk of
infections, sepsis and septic shock, despite prophylactic antibiotics.
However, antiviral medications, such as acyclovir and valacyclovir, are
quite effective in prevention of HSCT-related outbreak of herpetic
infection in seropositive patients. The immunosuppressive agents
employed in allogeneic transplants for the prevention or treatment of
graft-versus-host disease further increase the risk of opportunistic
infection. Immunosuppressive drugs are given for a minimum of 6-months
after a transplantation, or much longer if required for the treatment of
graft-versus-host disease. Transplant
patients lose their acquired immunity, for example immunity to childhood
diseases such as measles or polio. For this reason transplant patients
must be re-vaccinated with childhood vaccines once they are off
immunosuppressive medications.
Subscribe to:
Post Comments (Atom)
Great diagrammatic explanation.
ReplyDeleteBone marrow is the soft, spongy part in the centre of your bones where blood cells are produced.
The bone marrow contains stem cells, which are early stage cells that produce other cells.
Each tissue in the body contains stem cells that renew and replace that tissue when needed due to damage.
Haemopoietic stem cells generate all blood cells in the human body, including red cells, white cells and platelets.
For any type of clinical services like primary care, ob/gym, urology, pulmonology, contact Dr. Won Sam Yi
I wanted to thank you for this great read!! I definitely enjoying every little bit of it I have you bookmarked to check out new stuff you post. Dr. Ernesto Lee
ReplyDeletePositive site, where did u come up with the information on this posting?I have read a few of the articles on your website now, and I really like your style. Thanks a million and please keep up the effective work. dental implant CE
ReplyDelete