The "edrophonium test"
is infrequently performed to identify MG; its application is limited to
those situations in which other investigations have failed to yield a
conclusive diagnosis. This test requires the intravenous administration
of edrophonium chloride (Tensilon, Reversol) or neostigmine
(Prostigmin), drugs that block the breakdown of acetylcholine by
cholinesterase (acetylcholinesterase inhibitors) and temporarily
increases the levels of acetylcholine at the neuromuscular junction. In
people with myasthenia gravis involving the eye muscles, edrophonium
chloride will briefly relieve weakness.
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