The primary result of mitosis
is the transferring of the parent cell's genome into two daughter
cells. These two cells are identical and do not differ in any way from
the original parent cell. The genome is composed of a number of
chromosomes—complexes of tightly coiled DNA that contain genetic
information vital for proper cell function. Because each resultant
daughter cell should be genetically identical to the parent cell, the
parent cell must make a copy of each chromosome before mitosis. This
occurs during the S phase of interphase, the period that precedes the
mitotic phase in the cell cycle where preparation for mitosis occurs.
Each
chromosome now has an identical copy of itself, and together the two
are called sister chromatids. The sister chromatids are held together by
a specialized region of the chromosome: a DNA sequence called the
centromere. The "real" process of mitosis begins
when the chromosomes condense and become visible. In most eukaryotes,
the nuclear membrane which segregates the DNA from the cytoplasm
disintegrates into membrane vesicles. The nucleolus which make ribosomes
in the cell also dissolves. The chromosomes align themselves in a line
spanning the cell. Microtubules — essentially miniature strings— splay
out from opposite ends of the cell and shorten, pulling apart the sister
chromatids of each chromosome. As a matter of convention, each sister
chromatid is now considered a chromosome, so they are renamed to
daughter chromosomes. As the cell elongates, corresponding daughter
chromosomes are pulled toward opposite ends. A new nuclear membrane
forms around the separated daughter chromosomes.
As mitosis completes,the
cell begins cytokinesis. In animal cells, the cell pinches inward where
the imaginary line used to be (the area of the cell membrane that
pinches to form the two daughter cells is called the cleavage furrow),
separating the two developing nuclei. In plant cells, the daughter cells
will construct a new dividing cell wall between each other. Eventually,
the parent cell will be split in half, giving rise to two daughter
cells, each with a replica of the original genome.
Prokaryotic
cells undergo a process called binary fission which is very much
different from the process of mitosis, because of the non-involvement of
nuclear dynamics and lack of linear chromosomes.
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